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However, when the researchers taken out DNA methylation from the cancer tumor cells, the loops loosened somewhat, back to the continuing state of an embryonic cell, plus some gene expression was restored. DNA methylation is a standard cellular process, however when it will go and genes are improperly methylated awry, it could shut down important tumor suppressing cell functions. Demethylating agents, medicines that target and remove unusual DNA methylation from genes, have been launched as potential brand-new cancer therapies. For these therapies to be effective fully, Baylin says, researchers could also need to search for agents that disrupt PcG loops.. Chromatin product packaging helps decipher how cancers develops To decipher how tumor develops, Johns Hopkins Kimmel Tumor Center investigators say researchers must take a closer consider the packaging.