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The Philadelphia chromosome, which occurs in 2 to 5 % of children with ALL, can be an abnormal chromosome that occurs in several types of childhood and adult leukemias sometimes. It arises whenever a piece of chromosome 9 fuses with a chromosome 22. The fusion outcomes in an abnormal proteins that plays a significant part in the malignancy. Grants from the National Cancers Institute and from the governments of participating countries supported this research. James Cancer Hospital and Richard J. Solove Research Institute is usually a founding person in the National Comprehensive Tumor Network. The James Cancers Hospital is ranked by U consistently.S.. Chromosome losses can signal an especially poor response to therapy A new international study of children with a severe type of acute lymphoblastic leukemia demonstrates particular chromosome losses can signal an especially poor response to therapy, but that various other chromosome abnormalities have no effect on treatment survival.