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.. Association between Pak1 expression and subcellular localization and tamoxifen level of resistance in breast cancer patients A protein that activates estrogen receptors in breast cancer may play a role in resistance to therapeutic ramifications of anti-estrogen tamoxifen treatment, regarding to a scholarly research in the Journal of the National Cancer Institute. Pak 1 is an associate of a family of proteins involved with many cell functions, such as gene expression, cell motion, and cell death. Prior studies have suggested that the presence of this protein can lead to more invasive breast cancer. Goran Landberg, M.D., Lund University in Malmv, Sweden, and colleagues examined Pak1 expression in 403 premenopausal ladies with breast cancer.